http://www.biologynews.net/archives/2011/03/01/answers_to_a_rare_and_tragic_form_of_epilepsy.html
In teens there is a disease appearing called Lafora disease. It is genetic and caused by improper glycogen buildup. The enzyme glycogen synthase usually gets on glucose molecules, but about 1 out of 10000 glucose molecules it attaches to a phosphate molecule. They release lafora bodies which are bodies of acid mucopolysaccharides into the brain and neurons. Because glycogen constantly breaks and builds up it gives the phosphate time to build up and cause chemical defects in the glycogen. Scientists are blaming glycogen synthase for the disease.
For those who don't know, epilepsy is a nervous system condition that stops signals to the brain. Glycogen is what stores energy in the liver and present in muscles. Lafora disease is quite painfull if you think about it. It degrates your energy while "poisoning" your nervous system. The comparison to mice shows that that it is most common in us. the second gene leading to the disease sounds like a possible link to finding a solution
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